Chronic Venous Thrombosis: Relief with Adjunctive Catheter-Directed Therapy (C-TRACT)

C-TRACT(Chronic Venous Thrombosis: Relief with Adjunctive Catheter-Directed Therapy) is a multicenter, randomized trial led by Sctract.PNGuresh Vedantham, MD, FSIR, of the Mallinckrodt Institute of Radiology, Washington University in St. Louis. It is funded by the National Heart, Lung and Blood Institute (NHLBI) within the National Institutes of Health (NIH). The study goal is to determine if the use of image-guided endovascular therapy (EVT) is an effective strategy to reduce the severity of post-thrombotic syndrome (PTS) and improve quality of life (QOL) in patients with established disabling iliac-obstructive post-thrombotic syndrome (DIO-PTS).   

The study is planning to enroll approximately 374 subjects at 20–40 clinical centers. All subjects will be asked to return for follow-up visits at 2, 4, 6, 12, 18, and 24 months post-randomization. Patient eligibility can be found in the protocol synopsis

SIR Foundation encourages SIR members to participate in this important effort to support evidence-based IR care by serving as site investigators or by referring patients to study sites.


Get involved

Clinical centers

C-TRACT is planning to recruit between 20–40 clinical centers, which are selected based on site selection criteria. Interested sites are required to complete and submit the C-TRACT Study Site Questionnaire


Health provider referral tool

C-TRACT will enroll approximately 374 subjects. To reach this enrollment goal, an innovative mobile application was developed to refer potential patients to participating sites. The C-TRACT Referral Tool app is designed to help physicians submit patient referrals securely and conveniently. The C-TRACT referral tool app can be downloaded to your mobile device.

Health provider referral tool


To find a list of publications related to this study, please visit the Washington University School of Medicine in St. Louis' scientific articles on New Image-Guided Treatments that Target Blood Clots.


Current C-TRACT Clinical Centers

The following sites are currently active in the C-TRACT study. For more information about the sites, please visit this page

  • Christiana Care Health Services, Inc. 
    • Research Coordinator: Ann Marie LeNoir
    • Site PI: Dr. Daniel Leung
  • Gunderson Health Systems
    • Research Coordinators: Sara Meyers
    • Site PI: Dr. Ezana Azene
  • Jobst Vascular Institute
    • Research Coordinator: Krisztina Hanus
    • Site PI: Dr. John Fish
  • Medical College of Wisconsin 
    • Research Coordinator: Elizabeth Weil
    • Site PI: Dr. Eric Hohenwalter
  • NorthShore University Health System
    • Research Coordinator: Marisa Durante
    • Site PI: Dr. Alfonso Tafur
  • Northwestern University Feinberg School of Medicine
    • Research Coordinator: Kristie Kennedy
    • Site PI: Dr. Kush Desai
  • NYU Medical Center
    • Research Coordinator: Resma Gadde
    • Site PI: Dr. Vikram Rajpurohit
    • St. Joseph Hospital 
      • Research Coordinator: Alfonso Soriano
      • Site PI: Dr. Bhavraj Khalsa
      • Temple University Hospital 
        • Research Coordinator: Jennie Wong
        • Site PI: Dr. Riyaz Bashir
      • Thomas Jefferson Hospital 
        • Research Coordinator: Kristen Bradigan
        • Site PI: Dr. Robert Ford
      • University of California - San Francisco
        • Research Coordinator: Khadija Siddiqua
        • Site PI: Dr. Kanti Kolli
      • University of Chicago
        • Research Coordinator: Pamela Lofton
        • Site PI: Dr. Osmanuddin Ahmed
        • University of Mississippi Medical Center
          • Research Coordinator: Pam McElroy
          • Site PI: Dr. Ajinkya Desai
        • University of North Carolina at Chapel Hill 
          • Research Coordinator: Zachary Gortler
          • Site PI: Dr. William Marston
        • University of Pittsburg
          • Research Coordinator: Julianna Sheline
          • Site PI: Dr. Eric Hager
        • University of Texas - Houston
          • Research Coordinator: Bridgett Hobbs
          • Site PI:  Mihir Patel, MD
        • University of Vermont Health Network - CVPH
          • Study Coordinator: Marjori Lahar, RN
          • Study PI: Steven Deso, MD
        • University of Virginia
          • Research Coordinator: Brigitte Kelly
          • Site PI: Dr. Minhajuddin Khaja
        • Washington University in St. Louis
          • Research Coordinator: Patricia Nieters
          • Site PI: Dr. Suresh Vedantham
        • Yale New Haven Hospital 
          • Research Coordinator: Patrice Lauture
          • Site PI: Dr. Cassius Iyad Ochoa Chaar

        Recent news

        • As of June 2023, C-TRACT has enrolled 175 participants and has 20 active slinical centers. Participating sites are encouraged to continue enrolling subjects.
        • On August 14, 2023, Dr. Vedantham and Dr. Roger Tomihama talked about the C-TRACT's status in Episode 43 of The Kinked Wire Podcast.
        • During SIR's 2023 Annual Meeting, Dr. Suresh Vedantham presented on the Monday Plenary Session. He presentation was titled "From ATTRACT to C-TRACT to PE-TRACT: How three IR-led landmark trials will
          define venous thromboembolism care and elevate our specialty.”
        • In the October 2022 IR Quarterly, Dr. Ahki Sista shared how Dr. Vedantham's ATTRACT and C-TRACT Trials can be used a model of IR research.

        Contact information

        If you have any questions about SIR Foundation's involvement in C-TRACT, please contact the Director of Research and Grants.