2004 Grant Recipient

Aneurismal Flow Dynamics in Swine Model – an In Vivo MR Phase Contrast Study at 3 Tesla

Shantanu Sinha, PhD
UCLA School of Medicine
Subarachnoid hemorrhage from ruptured aneurysms remains a devastating disease, continuing to produce one of the most severe forms of hemorrhagic stroke. A better understanding of the correlation between aneurismal flow dynamics and the natural history of cerebral

aneurysms will further benefit therapeutic decisions. A pretherapeutic, reliable evaluation of flow dynamics in these lesions might depict aneurysms at risk of rupturing. Dr. Sinha has hypothesized that hemodynamic indices extracted from the aneurismal flow patterns visualized with high resolution MR phase contrast imaging at 3T will provide in-vivo, non-invasive, clinically relevant markers of the aneurysm condition. The long-term goal of this study is to develop a better understanding of the correlation between aneurismal hemodynamics derived from MR imaging and the natural history of cerebral aneurysms.