HHMI Mentors

If interested in contacting any of the programs below for mentorship, please contact Audrey Ford.

Vascular and Interventional Translational Lab at Mayo Clinic

Lead: Sanjay Misra, MD, FSIR
Professor of Radiology
Vascular and Interventional Translational Lab at Mayo Clinic

The Vascular and Interventional Translational Lab at Mayo Clinic is interested in the developing translational therapies to treat venous stenosis formation associated with hemodialysis graft failure and developing nano imaging and nano drug delivery for acute kidney injury. Consisting of an 800 square foot laboratory is complete with a cell culture room and a microsurgical room with state of the art molecular biology capabilities.  There are two technicians and three post doctoral fellows who work in the laboratory.

Interventional Oncology Laboratory at Northwestern

Lead: Andrew Larson, PhD
Professor, Department of Radiology
Northwestern University Feinberg School of Medicine
Director, Center for Translational Imaging

The Interventional Oncology Laboratory, directed by Andrew Larson specializes in the pre-clinical development and clinical translation of image-guided cancer therapies. Specific research interests include the development of IO therapies for liver and pancreatic cancer along with associated imaging techniques for treatment planning and follow-up monitoring of therapy response. Current multi-disciplinary research efforts include the development and validation of innovative transcatheter approaches for targeted drug and brachytherapy delivery (drug eluting microspheres, nanotechnology, radioembolization microspheres), tissue ablation technology (photothermal and irreversible electroporation approaches), and targeted delivery of cellular and peptide-based immunotherapy.

Vanderbilt University Medical Center

Lead: Reed Omary, MD, MS, FSIR
Carol D. & Henry P. Pendergrass Professor and Chairman,
 Department of Radiology and Radiological Sciences
Professor of Biomedical Engineering
Director, Medical Innovators Development Program

Vanderbilt University Medical Center and its 41,000 square foot Vanderbilt University Institute of Imaging Science (VUIIS), lead by professor John Gore, includes one of the most extensive imaging research facilities in the nation. The proximity of VUIIS to the Vanderbilt University Hospital and to Vanderbilt’s Engineering School (each located across the street from VUIIS) have helped propel Vanderbilt Radiology to become ranked #7 in the nation in NIH funding. Interventional radiology research includes innovative NIH-funded programs in cancer, metabolism, molecular probes, medical devices, and informatics. There is also a long-term, extremely successful ongoing collaboration with the interventional oncology laboratory at Northwestern, led by Andrew Larson, PhD.

Yale-New Haven Hospital

Lead: Jeff Geschwind, MD, FSIR
Chairman Department of Radiology and Biomedical Imaging, Professor of Radiology and Oncology

World-renowned for its medical research and advances, the Yale-New Haven Hospital includes a variety of research centers and CORE facilities. Designed to encourage cutting-edge research in the areas of medicine, genetics, technology and others, these facilities enable our researchers to better medical treatments for a wide variety of health concerns. 

The Yale Translational Research Imaging Center (Y-TRIC): Founded in 2010 and directed by Albert Sinusas, MD, professor of medicine and of radiology and biomedical imaging, Y-TRIC was established to facilitate translational animal research. The facility centralizes small and large animal housing and surgery with state-of-the-art imaging resources. One of the newest additions to Y-TRIC, brought by Jeff Geschwind, MD, Chairman department of radiology and biomedical imaging, professor of radiology and oncology, is a state-of-the-art single plane fluoroscopic, angiographic, and cineradiographic x-ray suite (upto 60 frames per second) with sub-centimeter C-arm cone beam CT (CBCT) technology. This is a full clinical system (AlluraClarity, Philips Healthcare, Best, The Netherlands) with additional prototype hardware and software that is used for pre-clinical studies in order to accelerate the translation of new ideas and findings to the clinic. The facility is equipped with a multiple angulation angiocardiographic table to facilitate procedures. Support equipment includes computerized physiological monitoring and recording systems, dual channel electromagnetic and ultrasonic blood flow meters, ventilators, infusion pumps, a gas anesthesia unit, defibrillator and crash cart, powered contrast media injector, ample laboratory counter space and general laboratory equipment. The other core resources in Y-TRIC include a radiochemistry laboratory, a unique hybrid SPECT/64-slice CT scanner, a microSPECT/CT imaging suite, in vitro and in vivo microCT scanners, 3D ultrasound imaging systems, a state-of-the-art mouse echo core laboratory, and 3D graphics workstations.

Our research focuses on three major areas: 

    • Discovery and development of new cancer therapeutics designed to target the up-regulated tumor metabolism pathway.
    • Study, assessment and development (both clinically and pre-clinically) of new drug delivery platforms including nanoparticles and liposomes.
    • Development and validation of various imaging protocols to assess tumor response after loco-regional therapy for cancer.